|
KMID : 1123920050190030797
|
|
Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 3 p.797 ~ p.801
|
|
|
Aqueous Extract of Rosa rugosa Radix Dilates Vascular Smooth Muscle Via a NO-cGMP Pathway
|
|
Lee Jun-Kyoung
Li Hua Cao
Kang Dae-Gill
Lee Hyuck
Jang Ji-Yeon
Lee Ho-Sub
|
|
|
Abstract
|
|
|
|
While conducting an in vitro screening of various medicinal plant extracts, an aqueous extract of Rosa rugosa Radix (ARR) was found to exhibit a distinct vasorelaxant activity. ARR induced a concentration-dependent relaxation of the phenylephrine-precontracted aorta. This effect disappeared with the removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-]-quinoxalin-1-one (ODQ) completely inhibited the relaxation induced by ARR. ARR-induced vascular relaxations were also markedly attenuated by addition of diltiazem or verapamil. However, the relaxant effect of ARR was not blocked by pretreatment with indomethacine, tetraethylammonium (TEA), glibenclamide, atropine, or propranolol. Taken together, the present study suggests that ARR dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.
|
|
|
KEYWORD
|
|
|
Rosa rugosa Radix (ARR), vasorelaxation, NO/cGMp
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|